Abstract: A convenient method ensured the safety of airworthiness was developed to research the safety performance of aviation alternative fuel in case of lacking enough flight data of aviation alternative fuel,and it is almost impossible to evaluate the safety performance by limited engines and flight experiments. On the base of the fuel as one of the engine replacement parts, the safety of alternative fuels can be complied with compliance verification method, including to extract a fuel-independent safety criterion from the history experience and to compare the aero-engine safety of alternative fuels by similar analogy. The critical parameters with the characteristic parametric numerical description have been extracted on five levels: fuel specification level, fuel system level, component level, engine level and aircraft level. The work margin of critical parameters obtained from alternative fuel are analogized with the safety margin of critical parameters based on kerosene flight experience, and accordingly the results can be analyzed and identified the safety of aero-engine in alternative fuel. This certification process help to achieve on the safety of alternative fuel and the cost on the refining fuel required as same as kerosene. Accordingly, the safety margin can bridge the gap from kerosene flight experiences to aviation alternative fuel safety certification. The optimization methodologies for the production and distribution of alternative fuel will be established based on the safety sensitivity analysis of aero-engine and a fuel-independent safety standard.