Manson-Coffin equation,Ostergren method and microcrack propagation model were chosen to predict TMF life in DS Superalloy DZ125.The results of TMF life prediction showed that all of methods chosen were able to give a reasonable life prediction result for DS superalloy DZ125.For in-phase TMF,in-phase with hold time TMF and -135° phase angle TMF,Ostergren model gave a better life prediction result than Manson-Coffin equation and microcrack propagation model did. But for out-of-phase TMF,microcrack propagation model gave better results than Ostergren model and Manson-Coffin equation did.