By employing orthogonal experiment design method to build up an initial database and approximate response surface model of quadric polynomial,this paper presented a concurrent subspace optimization process of hypersonic cruise vehicle(HCV) for airframe/scramjet integrated shape parameters and trajectory parameters based on multi-restricted and multi-disciplinary conditions.Through the optimization process,the optimal shape and trajectory parameters on multi-disciplinary synergetic conditions were acquired,providing a reference scheme of HCV for further detailed design.