某轴流式血液泵的实验与改进设计

展昭; 张岩; 桂幸民

某轴流式血液泵的实验与改进设计

1.
北京航空航天大学能源与动力工程学院, 北京 100083
2.
中国协和医科大学阜外医院心脏外科, 北京 100037

基金项目: 国家自然科学基金(50676004);国家高科技研究发展计划(863)基金(2006AA02Z4D);北京市优势专科疾病防治研究基金(H030930020130)

计量
- 文章访问数: 1794
- HTML浏览量: 67
- PDF量: 456
- 被引次数: 0
出版历程
- 收稿日期: 2007-05-24
- 修回日期: 2007-06-25
- 刊出日期: 2008-06-28

Experiment and design improvement of an axial flow blood pump

1.
School of Jet Propulsion, Beijing University of Aeronautics and Astronautics, Beijing 100083, China
2.
Department of Cardiac Surgery, Fuwai Hospital, Peking Union Medical College, Beijing 100037, China

摘要

摘要: 原型血液泵LAP-00的数值模拟及实验结果表明,在设计转速9000r/min下,最大效率点对应的设计点流量为11L/min,远大于临床所需3⁸L/min的流量,致使血液泵在实际应用时效率偏低;而静子区域存在的流动分离与回流,极易造成血流停滞进而引发血栓.改进后的血液泵LAP-23,将设计转速从9000r/min降低至8000r/min,减小了转子叶尖切应力对血细胞的破坏;设计点流量降低至6L/min,并消除了静子区域内的分离和回流.
- 血液泵 /
- 轴流 /
- 数值计算 /
- 溶血 /
- 血栓
Abstract: The numerical investigation and experimental results of the proto-pump LAP-00 show that at design rotational speed of 9000 r/min,the flow rate corresponding to the highest efficiency point is 11 L/min,which is much higher than clinical use(3⁸ L/min),causing the pump to work at off design point in clinic use with a low efficiency.Besides,in the diffuser region,flow separation and recirculation may cause blood stagnation and thrombosis.The improved design for pump LAP-23 decreases the design rotational speed from 9000 r/min to 8000 r/min,thus reduces the high shear stress on blood cells at impeller tip;meanwhile,it decreases the design flow rate to 6 L/min and eliminates flow separation and recirculation in the diffuser region.
- blood pump /
- axial flow /
- numerical simulation /
- hemolysis /
- thrombosis

HTML

参考文献(14)

[1]	云忠,龚中良.旋转叶轮血泵的发展与展望[J].生物医学工程学杂志,2005,22(1):151-154.YUN Zhong,GONG Zhongliang.Development and expectation of rotary impeller blood pump[J].J Biomed Eng,2005,22(1):151-154.
[2]	Greg W B.James F A,Wu Z J,et al.Computational fluid dynamics as a development tool for rotary blood pump[J].Artificial Organs,2001,25(5):336-340.
[3]	王芳群,曾培,封志刚,等.应用CFD研究叶轮设计对人工心脏泵内流场的影响[J].中国生物医学工程学报,2005,24(5):578-582.WANG Fangqun,ZENG Pei,FENG Zhigang,et al.An investigation of effect of impeller design on flow patterns in blood pumps with CFD[J].Chinese J Biomed Eng.2005,24(5):578-582.
[4]	Kerkhoffs W,Schumacher O,Meyns B.Design,development,and first in vivo results of an implantable ventricular assist device,MicroVad[J].Artificial Organs,2004,28(10):904-910.
[5]	Apel J.Paul R.Klaus S,et al Assessment of hemolysis related quantities in a microaxial blood pump by computational fluid dynamics[J].Artificial Organs,2001,25(5):341-347.
[6]	薛嵩,张岩,桂幸民.运用三维数值模拟对人工心脏血液泵的设计和改进[c]//北航第二届研究生学术论坛文集.北京:北京航空航天大学出版社,2005.XUE Song,ZHANG Yan,GUI Xingmin.Digital stimulation to development of axial pump for artificial heart[C]//Collected works of the 2nd Postgraduates' Forum of BUAA.Beijing:BUAA Press,2005.
[7]	Huang C R,Fabisiak W.A rheological equation characterizing both the time dependent and the steady state viscosity of whole human blood[R].AICHE Symposium Series,1978:19-21.
[8]	Wells R E,Merrill E W.Shear rate dependence of the viscosity of whole blood and plasma[J].Science,1961(133):763-764.
[9]	Untaroiu A,Wood H G.,Allaire P E,et al.Computational design and experimental performance testing of an axial flow pediatric ventricular assist device[J].ASAIO Journal 2005,(51):629-635.
[10]	Tetsuya Yano,Kazumitsu Sekine,Ayumi Mitoh,et al.An estimation method of hemolysis within an axial flow blood pump by computational fluid dynamics analysis[J].Artificial Organs,2003,27(10):920-925.
[11]	Apel J,Neudel F,Reul H.Computational fluid dynamics and experimental validation of a microaxial blood pump[J].ASAlO,2001.(47):552-558.
[12]	Giersiepen M.Wurzinger L J,Opitz R,et al.Estimation of shear stress-related blood damage in heart valve prostheses-in vitro comparison of 25 aortic valves[J].Artif Organs,1990,13:300-306.
[13]	Bludszuweit C.Three-dimensional numerical prediction of stress loading of blood particles in a centrifugal pump[J].Artif Organs,1995,19:590-596.
[14]	Paul R,Apel J,Klaus S,et al.Shear stress related blood damage in laminar couette flow[J].Artif Organs,2003.27:517-529.