Abstract: The vibration of the satellite was analyzed,and a mathematical model of real-time pointing and tracking system was built up.An immune feedback proportional integral differential(PID)controller based on fuzzy rules was presented,of which including an active term controlling the response speed and an inhibitive term controlling the stabilization effect;a fuzzy logic was implemented to approach the inhibitive term.Also,the genetic algorithm was adopted for parameter selection according to its optimizing characteristic.At last,simulation results verify the vibration suppression performance and show the highly robust and efficient controller design.