Abstract: Based on the procedure of the parametric design and numerical simulation of the fan,investigations were made in detail on the effect of various design parameters on the aerodynamic performance of the fan,which can provide deep understanding for the optimization of the fan.The multi-parameter constrained optimization procedures based on the combination algorithms of design of experiments(DOE),response surface models(RSM),genetic algorithm(GA) and mixed integer optimization(MOST),were carried out on 8025 fan for maximizing the coefficient of flow rate over the operating range rather than at a single operating condition with parallel computational fluid dynamics(CFD).Results show that aerodynamic average performance of the optimal fan is increased by 14.5 % when compared to the initial fan.